(1) Establishing the extracorporeal membrane oxygenation technique (ECMO) system for severe respiratory failure in China.

We conducted the first multi-center clinical collaboration study of ECMO in China, set up the largest ECMO treatment center for respiratory failure in China, and accomplished the nationally greatest number of ECMO for the treatment of respiratory failure, with nearly 120 cases at present. Moreover,  the nationally first guidelines about clinical application of ECMO in treating severe respiratory failure, Suggestions about clinical procedures of extracorporeal membrane oxygenation in severe adult respiratory failure, was drafted.

(2) In-depth study on the pathogenic mechanism of ventilator-related lung injury and repair mechanism following lung injury, providing abundant theory basis for pulmonary protective ventilation of ARDS, and improving the safety about clinical application of mechanical ventilation. Moreover,  a book called Guidelines (trial) of mechanical ventilation for acute respiratory distress syndrome was drafted.

(3) Proposing early diagnosis strategies and diagnostic standard of acute aggravation of COPD combined with invasive pulmonary aspergillosis. Clinical features of the disease were prospectively summarized, and the nationally largest clinical and specimen bank was established. 2 papers were cited as referencefor guidelines of aspergillosis diagnosis and treatment issued by Infection Disease Society of America in 2016.

(4) Setting up clinical data and biological specimen bank of various diseases, including ARDS (about 460 cases), ECMO cases (about 120 cases), COPD combined with pulmonary aspergillosis (about 100 cases) and pneumocystis carinii (about 96 cases), etc. The information management system of the specimen bank was completed, providing an important basis for the future clinical study.

(5) Based on the research achievements above, a series of respiration supporting technique training courses, including airway management and lung rehabilitation, noninvasive ventilation, invasive ventilation, breathing mechanics, and ECMO, etc., which were provided for 6-8 times each year, were created. Over 1,200 students were cultivated each year, and this center became an important respiration supporting technique training center nationally, promoting clinical application of respiration supporting techniques in China.